产品货号：
Z25376
中文名称：
RAP80 UIMC1抗体
英文名称：
Anti-RAP80 UIMC1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RAP80 UIMC1 Antibody |
| 指标别名 | ubiquitin interaction motif containing 1;RAP80;X2HRIP110;UIMC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | UIMC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | RAP80 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RAP80.The immunogen is located within amino acids 520 - 570 of RAP80. |
| 计算分子量 | 80kDa |
| 成分 | RAP80 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | RAP80 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR).Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1,allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation.Both RAP80 and CCDC98 are required for DNA damage resistance,G2-M checkpoint control,and DNA repair.Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation,although not as much as in BRCA1-depleted cells,suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1.At least four isoforms of RAP80 are known to exist. |
| Uniprot ID | Q96RL1 |
| 基因名全称 | Ubiquitin interaction motif containing 1 |
| 蛋白名全称 | Ubiquitin interaction motif containing 1 |
| 推荐稀释比 | RAP80 antibody can be used for detection of RAP80 by Western blot at 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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